锶的成骨机制及富锶食品的研发现状

Osteogenic Mechanism of Action of Strontium and Research and Development Status of Strontium-rich Foods

摘要:

锶是人体必需的一种微量元素，广泛分布于人体组织内，骨骼是其最大的“储存库”，约99%的锶都以离子形式存在于其中。锶可从多方面对骨骼健康产生广泛而深远的影响，在临床上药物雷奈酸锶可以通过影响骨代谢从而为骨骼健康保驾护航已成为一种共识，但其是一种人工合成化学品，安全性远不如天然锶盐类，故而研发富锶食品从而使人们通过日常膳食途径就可以达到呵护骨健康的目的正在逐渐成为研究热点。该研究就常见骨科疾病的发病类型、锶对骨代谢的作用机制及食品型锶制品的现状及开发进行综述，重点探讨了锶可同时调节成骨细胞和破骨细胞的双重成骨机制以及富锶食品现状，为锶在骨科疾病上的应用及富锶食品更好的开发提供理论依据。

Abstract:

Strontium is an essential trace element widely distributed in human tissues, with bone being its largest "reservoir", in which approximately 99% of strontium is present in the ionic form. Strontium has a considerable impact on bone health, and hence there is wide research consensus that the clinical drug strontium ranelate can protect bone health by influencing bone metabolism. However, as it is a synthetic chemical that is less safe than natural strontium salts, the development of strontium-rich foods which will aid individuals to care for their bone health through their daily dietary routine, has garnered increasing research attention. This paper reviews the types of common orthopedic diseases, the mechanism of action of strontium on bone metabolism, and the current status and development of food-based strontium products, focusing on the dual osteogenic mechanism of strontium regulating both osteoblasts and osteoclasts and the current situation of strontium-rich foods. The findings of this study providea theoretical basis for the application of strontium in orthopedic diseases and the improved development of strontium-rich foods.