该研究旨在制备岩藻黄质固体脂质微胶囊（Fucoxanthin Solid Lipid -Core Microcapsules，FX-MC）并对其进行表征。通过单因素试验与响应面分析对微胶囊制备工艺条件进行优化，采用扫描电子显微镜、粒径-zeta电位联用仪、傅里叶红外光谱仪、差示扫描量热仪对微胶囊理化性质进行表征。结果表明：最佳微胶囊工艺条件为：棕榈硬脂:胆固醇60:40（m/m）、FX:脂质0.2:1（m/m）、壁芯比25:1（m/m）、凝聚pH值4.5，超声条件240 W/3 min，所得微胶囊包埋率为96.24%，载药量为0.85%。冻干样品后，FX-MC平均粒径为1,154 nm，PDI值为0.27，电位为-20.71 mV，粒径分布较均匀，溶液较为稳定；红外光谱图分析可知，岩藻黄质被微胶囊壁壳成功包埋；差示扫描量热谱图可知，FX-MC发生相变所需的焓值最高，热稳定性明显提高。该研究结果可为岩藻黄质在食品或保健品行业的进一步开发应用提供参考。

Fucoxanthin solid lipid-core microcapsules (FX-MC) were prepared and subsequently characterized in this study. The conditions for the preparation of the microcapsules were optimized through a single factor experiment using the response surface methodology (RSM). Physiochemical properties of the microcapsules were then characterized using a scanning electron microscope (SEM), particle-size zeta potential analyzer, Fourier-transform infrared spectrometer (FT-IR), and a differential scanning calorimeter (DSC). The results revealed that the best microencapsulation process conditions were: Palm stearin: cholesterol 60:40 (m/m), FX:lipid 0.2:1 (m/m), wall-to-core ratio 25:1 (m/m), pH 4.5, and ultrasonic condition 240 W/3 min. The resultant encapsulation rate of the microcapsules was 96.24%, with a drug loading rate of 0.85% After freeze-drying the samples, the average particle size of the FX-MCs was 1 154 nm, with a PDI value of 0.27, and potential of -20.71 mV. A uniform particle size distribution and relatively stable solution was obtained. FT-IR analysis showed that fucoxanthin was successfully encapsulated within the microcapsule wall shell. DSC analysis confirmed that the highest enthalpy was required for FX-MC during phase change, and thermal stability showed a remarkable improvement. The results of this study can provide a reference for the further development and application of fucoxanthin in the food and healthcare industries.

福建省科技计划项目（2021N0029）；自然资源部第三海洋研究所基本科研业务费专项资金资助项目（2022006；2017026）；福建省海洋经济发展资金项目（FJHJF-L-2021-4）；厦门市科技计划项目（3502Z20221036）；厦门海洋研究开发院共建项目（K210103）