骆驼初乳对环磷酰胺诱导小鼠免疫功能低下的调节作用

Effects of Camel Colostrum on Cyclophosphamide-induced Immunodeficiency in Mice

摘要:

本文研究骆驼初乳对免疫低下小鼠免疫功能的影响。采用环磷酰胺腹腔注射法建立免疫低下小鼠模型，用不同剂量的骆驼初乳灌胃，30 d后检测免疫学指标，观察骆驼初乳免疫调节功能。用骆驼初乳和酪蛋白饲养小鼠，计算骆驼初乳食物转化率及蛋白质功效比值。骆驼初乳高剂量组T淋巴细胞阳性率和白细胞数分别是免疫低下组的2.2倍和1.4倍（p<0.05）；中剂量和高剂量骆驼初乳能够显著提高免疫低下小鼠CD4+/CD8+比值和IgG水平（p<0.05）以及巨噬细胞的吞噬能力和免疫器官指数，同时能有效修复脾脏组织病理损伤；骆驼初乳的蛋白质利用率为85.05%，矫正蛋白质功效比值为3.17；本研究表明骆驼初乳可以增强免疫低下小鼠的免疫功能，对环磷酰胺诱导的免疫器官损伤有明显修复作用，骆驼初乳蛋白质为优质蛋白，更容易被吸收，更有助于免疫活性蛋白发挥免疫调节功能。

Abstract:

In this paper, the effect of camel colostrum on immune function in immunocompromised mice was investigated. A 30-day gavage experiment using Kunming mice was performed to explore the immune regulation of camel colostrum on cyclophosphamide (CY)-induced immunodeficiency and immune injury by immunological parameters. The mice were fed with camel colostrum and casein to calculate the food conversion rate and protein efficacy ratio of camel colostrum. The percentage of positive lymphocyte and the count of white blood cells in the high dose group of colostrum were 2.2 times and 1.4 times higher than those in the immunocompromised group, respectively (p<0.05). Medium and high dose of camel colostrum can significantly increase CD4+/CD8+ ratio, IgG level (p<0.05), phagocytic capacity and immune organ index of macrophage in immunocompromised mice. Moreover, camel colostrum can effectively repair the damage of immune organs in mice. The protein utilization rate of camel colostrum is 85.05%, and the corrected protein efficacy ratio is 3.17. In conclusion, camel colostrum has the effect of enhancing immune function in immunocompromised mice. Camel colostrum protein is a high-quality protein that is more easily absorbed to exert immunoregulatory functions. In addition, camel colostrum could be a promising, potent immunomodulatory therapeutic agent for various immune disorders.