为明确荔枝果肉的生物抗氧化和抗肿瘤保健功能，采用HepG2人肝癌细胞模型对我国南方地区主要种植的10种代表性荔枝品种果肉的细胞抗氧化活性（CAA值）和抗肿瘤细胞增殖活性进行了评价。结果表明，10种荔枝品种中，妃子笑荔枝果肉具有最大的CAA值，淮枝则最小；妃子笑抗HepG2肿瘤细胞增殖活性最强，糯米糍则最弱。荔枝果肉的CAA值与总多酚含量、总黄酮含量、多酚化学抗氧化能力指数（ORAC值）之间都有极显著的正相关性（p<0.01），且与黄酮含量之间正相关性最大，说明荔枝果肉中起生物抗氧化作用的主要成分是黄酮类化合物；但荔枝果肉对HepG2肿瘤细胞的抗增殖活性与总多酚含量、总黄酮含量、ORAC和CAA值之间均呈现较弱的负相关性（p>0.05），提示某些特殊酚类单体或其协同作用在抗肿瘤细胞增殖过程中发挥主要作用。

The celluar antioxidant activity (CAA) and antiproliferative activitiy of 10 representative litchi (Litchi chinensis Sonn.) cultivars in southern China were evaluated by HepG2 model to investigate the bio-antioxidant and antineoplastic functions of different litchi cultivars in this study. The results showed that Feixixiao had the largest CAA value among the ten litchi cultivars and the Huaizhi was the smallest; Feizixiao had the strongest antiproliferative activity on HepG2 cells and the Nuomici was the weakest. The CAA value of litchi pulp exhibited a significant positive correlation with total polyphenols, total flavonoids and ORAC (oxygen radical absorption capacity) values (p<0.01), and had the highest correlation with total flavonoids, indicating that the main component of biological antioxidants in litchi pulp was flavonoids. However, there was a weak negative correlation between antiproliferative activity of litchi pulp and total polyphenols, total flavonoids, ORAC and CAA values, indicating that some special polyphenol individuals or their synergies played a key role in antiproliferation of tumor cells.

深圳市科技计划项目（JCYJ20140901162541286、JCYJ20160530173755124）