评价长期饲喂低血糖指数(GI)挂面对链脲佐菌素(STZ)诱导的糖尿病大鼠糖脂代谢的改善作用。选用32只成年SD雄性大鼠，按血糖值随机分成4组，每组8只，分别为普通挂面正常组和糖尿病组、低GI挂面正常组和糖尿病组，饲喂4周解剖测定糖脂指标。结果表明：低GI挂面膳食纤维高达16.04%。低GI挂面能增加糖尿病大鼠的体重、血清胰岛素、肝糖原和肌糖原；减少采食量和血清糖化蛋白，使空腹血糖和脏器指数下降，改善糖耐量异常。而且低GI挂面还能降低糖尿病大鼠血清中的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)，增加血清中的高密度脂蛋白胆固醇(HDL-C)，使肝脏中总脂肪和脂肪浓度显著下降。正常大鼠两组间糖脂的各项指标无差别，说明低GI挂面对正常大鼠无影响，而对糖尿病大鼠的高血糖症状和脂代谢紊乱有改善作用，在预防治疗糖尿病方面具有重要意义。

The effects of fine dried noodles with a low glycemic index (GI) on glucolipid metabolism of streptozotocin (STZ)-induced diabetic rats were investigated. Based on the blood glucose level, thirty-two adult male Sprague-Dawley (SD) rats were randomly divided into four groups: ordinary dried noodle control group, ordinary dried noodle diabetic group, low GI dried noodle control group, and low GI dried noodle diabetic group. After a four-week feeding, the blood glucose and lipid indexes were determined. The results showed that the dietary fiber content in low GI noodles was relatively high, up to 16.04%. The low GI noodles increased body weight and the levels of serum insulin, hepatic glycogen, and muscle glycogen in diabetic rats. The low GI noodles also reduced food intake and glycosylated serum protein (GSP) levels, decreased fasting blood-glucose (FBG), decreased the relative weights of various organs, and improved impaired glucose tolerance. Additionally, low GI dried noodles reduced the levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) in serum while increasing the serum high-density lipoprotein cholesterol (HDL-C) level in diabetic rats. As a result, the liver total lipid and lipid concentrations were significantly decreased. The blood glucose and lipid indices of the two control groups were similar, indicating that the low GI dried noodles did not affect normal rats. This study demonstrates that low GI dried noodles have some beneficial effects in improving hyperglycemia and lipid metabolism disorders in diabetic rats, which is of importance for the prevention and treatment of diabetes.

重庆师范大学基金项目资助（14XLB004）