拐枣多糖对糖尿病小鼠血糖血脂的影响

Effects of Polysaccharides Extractedfrom Hovenia acerba Lindl. on Glycemia and Lipidemia in Diabetic Mice

摘要:

研究拐枣多糖（Hovenia acerba Lindl.polysaccharide,HAP） 对四氧嘧啶诱导糖尿病小鼠血糖和血脂的影响。以腹腔注射四氧嘧啶（ALX）建立小鼠糖尿病模型，将建模成功的小鼠随机分为正常对照组、糖尿病模型组、HAP高、中、低剂量处理组、二甲双胍处理组、格列苯脲处理组和肾上腺素处理组。连续灌胃给药28 d，研究HAP对糖尿病小鼠空腹血糖（FBG）、糖化血红蛋白（HbAlc）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）等指标的影响。结果显示，HAP能明显降低正常小鼠血糖，能显著（p<0.01）降低肾上腺素引起的高血糖，能够有效降低糖尿病小鼠的FBG、HbAlc、TC、TG，升高HDL含量。拐枣多糖能够显著降低糖尿病小鼠血糖、改善血脂代谢紊乱。

Abstract:

The effects of Hovenia acerba Lindl. polysaccharides (HAPs) on blood glucose and blood lipids in alloxan (ALX)-induced diabetic mice were investigated in the present study. A mouse model of diabetes was established by intraperitoneal injection of ALX. The ALX-induced diabetic mice were randomly assigned to one of eight groups, including three HAP-treated groups (low-, medium-, and high-doses), a metformin-treated group, a glibenclamide-treated group, an epinephrine-treated group, an untreated diabetic model group, and a normal control group that was not treated with ALX. The HAPs were administered intragastrically for four weeks and the effects of HAPs on the levels of fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were investigated. The HAPs significantly reduced blood glucose in normal rats, markedly mitigated adrenaline-induced hyperglycemia, and effectively reduced serum FBG, HbAlc, TC, and TG, while increasing the concentration of HDL. These results suggest that HAPs can lower blood glucose and improve the metabolic disorders of blood lipids in ALX-induced diabetic mice.