绣线菊叶水煎液对小鼠的抗疲劳和抗氧化作用

Antifatigue and Antioxidant Effects of Spiraea salicifolia L. Leaf Decoction in Mice

摘要:

本文研究了绣线菊叶水煎液对小鼠的抗疲劳作用和抗氧化作用。对小鼠随机分组，灌胃不同剂量的绣线菊叶水煎液，并设立空白对照组，通过测定小鼠的负重游泳时间、肝糖原含量、肌糖原含量、血清尿素氮含量和全血乳酸含量来研究其抗疲劳作用；通过测定小鼠的过氧化氢酶含量和超氧化物歧化酶含量来研究其抗氧化作用。与空白对照组相比，给予低、中、高剂量绣线菊叶水煎液的小鼠的负重游泳时间分别增加了52.19%、167.11%、197.37%，肝糖原含量分别增加了68.94%、167.09%、195.81%，肌糖原含量分别增加了3.28%、19.67%、27.87%，血清尿素氮含量分别减少了14.89%、19.54%、35.27%，全血乳酸含量分别减少了14.59%、22.84%、33.21%；过氧化氢酶含量分别增加了15.48%、25.40%、53.57%，超氧化物歧化酶含量分别增加了19.59%、26.31%、38.29%。研究表明，绣线菊具有抗疲劳和抗氧化的作用，可用作功能保健产品原料，具有一定开发利用价值。

Abstract:

Antifatigue and antioxidant effects of Spiraea salicifolia L. leaf decoction in mice were investigated in this paper. Mice were randomly divided into different groups, and each group was administrated with different doses of .S. salicifolia L. leaf decoction by gavage; a blank control group was set up. The antifatigue effect of S. salicifolia L. leaf decoction was studied by the measurement of the weight-loaded swimming time, hepatic glycogen content, muscle glycogen content, serum urea nitrogen level, and lactate level in whole blood of mice; the levels of catalase and superoxide dismutase were measured in mice to study the antioxidant effect of the decoction. Compared with the blank control group, the changes of each indicator in mice administered low, medium, and high doses of S. salicifolia L. leaf decoction were as follows: the weight-loaded swimming time increased by 52.19%, 167.11%, and 197.37%, respectively; the hepatic glycogen content increased by 68.94%, 167.09%, and 195.81%, respectively; the muscle glycogen content increased by 3.28%, 19.67%, and 27.87%, respectively; the serum urea nitrogen level decreased by 14.89%, 19.54%, and 35.27%, respectively; the lactate level in whole blood decreased by 14.59%, 22.84%, and 33.21%, respectively; the catalase level increased by 15.48%, 25.40%, and 53.57%, respectively; the superoxide dismutase level increased by 19.59%, 26.31%, and 38.29%, respectively. Studies demonstrated that S. salicifolia L. had antifatigue and antioxidant effects; it could be used as a raw material for functional and healthy products and had certain development and utilization values.