以米荞1号为原料，采用响应面法优化荞麦中芦丁的提取工艺。在单因素试验的基础上，根据Box-Behnken 试验设计原理，通过响应面法优化芦丁提取工艺，选取时间、温度、料液比和甲醇体积分数四因素三水平进行中心组合试验，建立芦丁含量的二次回归方程，确定提取芦丁的最佳工艺组合条件。结果表明：提取时间93 min，提取温度77 ℃，料液比1:32，甲醇体积分数91%。该条件下芦丁提取含量预测值为17.92 mg/g，实测值为18.20 mg/g，偏差不大。

The response surface methodology was used to optimize the extraction of Fagopyrum of Miqiao 1. Based on one-factor-at-a-time experiments, the extraction of time, temperature, liquid-to-solid ratio and methanol concentration were used to carry out a 4-variable, 3-level central composite design, and established quadratic regression model. The best extraction time，temperature, solid-liquid ratio and methanol content were 93 minute, 77 ℃, 1:32 and 91 % under which the predicted yield of rutin with the optimized procedure was 17.92 mg/ and the practical yield of rutin was 18.20 mg/g.

国家科技支撑计划项目（2012BAI27B07）；四川省科技支撑计划（2011SZ0233）；现代农业产业技术体系建设专项资金资助（CARS-08-D-3）；四川中医药管理局课题（2010-78）