绿茶提取物的降血脂及减肥作用研究

Study of the Anti-obesity Function of Green Tea Extracts for Development of a Hypolipidemic Agents

摘要:

本实验以福建绿茶为原料，对其进行水提、茶渣醇提、残渣碱提，得到粗多糖、上清液、醇提物、粗蛋白四种提取物。以昆明小鼠为供试动物，喂食高脂饲料建立高脂肥胖模型，设置模型对照和正常对照，对四种提取物进行减肥降脂功效验证。结果表明：醇提物和上清液在调节血脂和控制体重方面效果较好，与模型组相比醇提物组TG和体重分别下降了37.50%、11.84%，上清液组TG和体重分别下降了35.42%、7.32%。粗蛋白和粗多糖只有一定的降血脂效果，与模型组相比TC分别下降了17.69%和9.52%，LDL-C下降了56.25%和42.97%。血清HL活力，醇提物组显著高于模型组；血清PL活力，上清液组显著低于模型组（P＜0.01）。

Abstract:

In this experiment, Fujian tea was treated by water extraction, alcohol extraction and alkaline extraction, giving crud polysaccharide, supernatant extracts, ethanol extracts and crude proteins. Using mice for the test animals by feeding them high-fat diet, high-fat obesity model was established. By setting model control and normal control groups, the weight-lose and lipid-lowering functions of four kinds of extracts were investigated. The results showed that, alcohol extract and the supernatant showed good effects on regulating blood lipids and weight control. Compared with model group, TG and body weight of the alcohol extract group decreased by 37.50% and 11.84%, respectively. TG and body weight of the supernatant extract group decreased by 35.42% and 7.32%, respectively. Compared with model group, crude protein and polysaccharide from Fujian tea showed lower lipid-lowering effec,. TC values of the mice in crude protein and polysaccharide groups decreased by 17.69% and 9.52%, respectively, and the LDL-C values of the mice decreased by 56.25% and 42.97%, respectively.In addition, HL activity in serum of the mice in ethanol extract group was significantly higher than that in the model group and the PL activity in serum of the mice in the supernatant group was significantly lower than that in the model group (P <0.01).