Research Progress on Natural Polysaccharides as Nanocarriers for the Treatment of Inflammatory Bowel Disease
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
Inflammatory bowel disease (IBD) is a chronic, multifactorial, recurrent disease characterized by immune system disorders and intestinal inflammation. Natural polysaccharides are pH-responsive, gastric tolerant, biodegradable and mucoadhesive by colonic microbiota, and have good anti-inflammatory and intestinal flora-regulating capacities, thereby being considered as ideal carriers for the design of novel preparations for IBD. Natural polysaccharides are used as nano-carriers to encapsulate drug targeting the colon, which not only improves the bioavailability of drugs, but also offers a synergistic therapy. This article reviews the mechanism underlying the synergistic treatment of IBD based on natural polysaccharide nanocarriers and the applications of polysaccharides as carriers in treating IBD.
