Preparation, Structural Characterization, and in Vitro Anti-inflammatory Activity of Coptis teeta Polysaccharide-selenium Nanoparticles
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Abstract:
The green synthesis of the traditional Chinese medicine, polysaccharide-selenium nanoparticles, was investigated to screen for selenium-rich polysaccharide health foods with antioxidant and anti-inflammatory functions to meet the increasing standards of living and the demand for better health. Coptis teeta-selenium nanoparticles (CTP-SeNPs) were prepared using the green reduction of sodium selenite by CTP and characterized and investigated for their in vitro antioxidant and anti-inflammatory properties. The results of Fourier transform infrared spectrometry and X-ray diffraction revealed that the CTP-SeNPs were successfully constructed. Energy dispersive X-ray spectroscopy-scanning electron microscopy and dynamic light scattering showed that the CTP-SeNPs appeared as thick flakes with rounded edges and had a selenium content of 11.66% and a particle size of about 101.96 nm. In vitro antioxidant assays showed that the free radical-scavenging ability of CTP-SeNPs gradually increased with an increase in the concentration in the range of 0~10 mg/mL, and the maximum scavenging rate was over 60%. The in vitro antioxidant effect of CTP-SeNPs was better than that of the CTP group. In vitro cell assays showed that CTP-SeNPs significantly promoted the proliferation of RAW264.7 cells as compared with CTP in the concentration range of 250~500 μg/mL. The anti-inflammatory activity of CTP-SeNPs in the concentration range of 250~1 000 μg/mL was better than that of CTP. In conclusion, CTP-SeNPs exhibits antioxidant and anti-inflammatory properties that may be potentially useful for the development of selenium-rich traditional Chinese medicine polysaccharide health foods.
