Gongcheng Oil Tea Attenuates Oxidative Stress in D-galactose-Induced Aging Mice
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Abstract:
Effect of Gongcheng oil tea on oxidative stress in D-galactose-induced aging mice was investigated. Healthy KM mice of reproductive age were randomly divided into 4 groups: normal control, aging model, Vc groups (100 mg/kg) and Gongcheng oil tea groups (750 mg/kg). The enzyme activity of glutathione peroxidase (GSH-Px) and superoxide dismutase (T-SOD), as well as the total antioxidant capacity (T-AOC) and malondialdehyde (MDA) level in serum, liver and kidney tissue of mice were determined. The pathological changes of liver and kidney tissues were observed. Gongcheng oil tea could significantly improve the liver and kidney indexes of mice that decreased by D-galactose (p<0.05). Compared with those of the aging group, the liver and kidney indexes of the oil tea group increased by 11.87% and 25.38% respectively. Pretreatment with Gongcheng oil tea, the enzyme activities of T-SOD and GSH-Px, as well as T-AOC levels in serum, liver and kidney tissue of mice increased significantly, while MDA production in serum, liver and kidney tissue of mice decreased significantly (p<0.05). Compared with the senescence group, GSH-PX, T-SOD and T-AOC in the liver of oil tea group increased by 62.98%, 98.35% and 714.63%, respectively (p<0.05), and MDA decreased by 65.42% (p<0.05). The activities of GSH-Px, T-SOD and T-AOC in kidney increased by 119.66%, 182.81% and 155.88% (p<0.05), respectively, while MDA decreased by 74.61% (p<0.05). Pathological observation showed that Gongcheng oil tea could alleviate liver and kidney damage during aging. The results showed that Gongcheng oil tea could inhibite aging-induced oxidative stress-related liver and kidney injuries in mice by attenuating oxidative stress.
