Residual Elimination of Furazolidone Metabolites in Crucian Carp under the Action of Different Antibiotics
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
In this article, the residue elimination rule of furazolidone metabolite 3-amino-2-oxazolidinone (AOZ) in crucian carp was studied after oxytetracycline, enrofloxacin, sulfamethoxine and furazolidone were administered in combination with bath. The results showed that furazolidone was rapidly metabolized into AOZ after entering the crucian carp, after the drug was stopped for 0 hours, the furazolidone control group had the highest residual AOZ in the kidney, liver, and muscle of the crucian carp, which were 88.87, 59.20, and 14.91 μg/kg, respectively, with an average elimination rate. 0.86, 0.52, 0.15 μg/(kg·h), respectively. Compared with the control group, the maximum residual concentration of AOZ in the kidney, liver, and muscle of crucian carp in the oxytetracycline-furazolidone group was significantly increased, which were 152.46, 125.39, 8.69 μg/kg, respectively, and the average elimination rate was 1.71, 1.17, 0.31 μg/(kg·h), respectively. However, the maximum residual concentration of AOZ in the kidney, liver, and muscle of Carassius auratus in the enrofloxacin-furazolidone group was significantly reduced compared with the control group, only 33.68, 49.77, 9.69 μg/kg, respectively, and the average elimination rate was 0.36, 0.31, 0.03 μg/(kg·h), respectively. The maximum residual amount of AOZ and the average elimination rate of AOZ in the crucian carp in the sulfamonomethoxine-furazolidone group were also different from those in the control group, but there was no significant change. After 96 hours of elimination, a large amount of AOZ remained in the crucian carp in each experimental group. It was initially found that in this experiment, AOZ is difficult to be eliminated in crucian carp. Oxytetracycline, enrofloxacin, and sulfamonomethoxine can affect the elimination of AOZ in crucian carp to varying degrees, and provides a theoretical basis for aquatic product quality and safety supervision and fishery drug residue research.
