Prediction the Targets and Pathways for Anti-obesity of Ginsenoside F2 by Network Pharmacology
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Abstract:
Ginsenoside F2 has various physiological functions, such as anti-cancer, liver protection, anti-inflammatory, and lipid-lowing. However, its mechanism of improving obesity is still unclear. Hence, the potential targets and mechanisms of ginsenoside F2 action for anti-obesity were analyzed by network pharmacology in this study. Targets information of ginsenoside F2 and obesity was collected from PubChem and GeneCards databases. After sharing targets, the G-F2-targets-obesity network was constructed and analyzed by means of CytoScape and other platform. The anti-obesity of ginsenoside F2 was related to a total of 35 potential targets, of which included MAPK1, VEGFA, CASP3, etc. GO enrichment suggested that potential targets were mainly involved in metabolism process, binding and cellular component formation. Moreover, it may play an anti-obesity effect through EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling pathway and neuroactive ligand-receptor interaction pathway. Network pharmacology successfully predicted the multi-targets and multi-pathways of ginsenoside F2, and it may provide a theoretical basis for further exploration of anti-obesity of ginsenoside F2.
