Preparation and Characterization of Eugenol/Starch Inclusion Compound Freeze-dried Powder
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Abstract:
The preparation technology of eugenol / starch inclusion compound freeze-dried powder was studied to improve its stability and accuracy in the application of medicine. The starch of naked oats was selected to encapsulate eugenol, and the preparation technology of the freeze-dried powder of eugenol starch inclusion compound was studied by ultrasonic method. The content of eugenol in the inclusion complex was determined by HPLC with inclusion rate as the index. The influence of the material ratio, ultrasonic temperature and ultrasonic time on the preparation of the inclusion complex was investigated by single factor test. The optimum technological conditions of the freeze-drying powder of eugenol starch inclusion compound were determined by the orthogonal test: the ratio of feeding materials was 10:0.8, the ultrasonic temperature was 50 ℃, the ultrasonic time was 50 minutes, and the inclusion rate was 44.54%. The order of influencing factors is: ultrasonic temperature>feeding ratio>ultrasonic time. The validation test for the preparation of eugenol/starch inclusion complex lyophilized powder was carried out by SEM, FT-IR and NMR The formation of eugenol/gelatinized starch inclusion complex freeze-dried powder was identified. In conclusion, the ultrasonic method was used to prepare eugenol/starch inclusion complex freeze-dried powder. The formation of eugenol/starch inclusion complex freeze-dried powder was verified. After the orthogonal experiment optimization of the preparation process, the inclusion rate reached 44.54%.
