Lipid-lowering Effects of Suaeda sulsa on Hyperlipidemia Rats
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Abstract:
In order to provide a reference for using Suaeda sulsa in the prevention and treatment of hyperlipidemia, the effect of Suaeda sulsa on blood lipids in the rats with hyperlipidemia was investigated. Fifty-six male SD rats were randomly divided into seven groups: the normal group, Suaeda sulsa prevention group, high-fat model group, positive control group, and Suaeda sulsa high-dose, medium-dose and low-dose intervention groups. Except for the normal group and prevention group, the other groups were fed with a high-fat diet. During the experimental period, the normal group and the model group were given the same amount of distilled water via oral gavage. After 6 weeks of intervention, the body weight, food intake, liver weight, periepididymal fat weight and serum lipid levels were measured. Results showed that compared with the high-fat model group, the body weight, food intake, liver weight and periepididymal fat weight of the intervention group and the Suaeda sulsa prevention group decreased, with the largest decreases being 22.20%, 34.72%, 37.17% and 60.06%, respectively. In terms of blood lipids, compared with the high-fat model group, the intervention group and the prevention group had lower TC, TG and LDL-C values (with the maximum decreases being 33.58%, 54.27% and 65.26%, respectively), but higher HDL-C value (increase by 53.95%). Compared with the positive group, the intervention group had similar TC level, same TG level, but significantly (p< 0.05) lower LDL-C value and higher HDL-C value. In particular, the high dose group exhibited the most significant impact: decreased LDL-C by 43.07% and increased HDL-C by 37.50%. Accordingly, Suaeda sulsa can prevent and control the increases of body weight, food intake, liver weight and periepididymal fat weight in rats with hyperlipidemia, and also prevent and reduce the abnormal increase of blood lipids.
