Lipid Metabolism of Compound Dendrobium officinale Leaf Ultrafine Powder on Hyperlipidemia Mice
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
To observe the effects of different proportions of compound Dendrobium officinale leaf ultrafine powder on the hyperlipidemia model mice induced by a high-fat and high-sugar diet. After successful modeling, the mice were administered with the compound Dendrobium officinale leaf ultrafine powder (with the ratio of the Dendrobium candidum leaf superfine powder to the refined extract of hawthorn as 1:1, 1:2, 1:4, 2:1, 4:1) for 8 weeks. The serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), glutamic-oxaloacetic transaminase (ALT), and alanine-glutamic transaminase (AST) were measured. After the last administration, the serum levels of superoxide dismutase (SOD), malondialdehyde (MDA) and oxidized low density lipoprotein (Ox-LDL) were measured. The cholesterol level in the liver was measured, and the liver tissue of the mice was examined by HE staining. The results showed that the compound Dendrobium officinale leaf ultrafine powder (at a ratio of 4:1) could effectively alleviate hyperlipidemia: decreased the serum levels of TC, LDL-c, MDA and Ox-LDL by 40.84%, 36.67%, 5.05% and 10.40% respectively (p<0.01), increased the serum SOD activity by 5.47% (p<0.01), decreased the liver TC level by 14.10% (p<0.01) and liver weight by 31.35% (p<0.01), and ameliorated liver fat deposition. The above results confirmed that the compound Dendrobium officinale leaf ultrafine powder (4:1) was effective and could ameliorate the dyslipidemia and liver lesions in mice induced by a high-fat and high-sugar diet.
