Anti-fatigue Effect and Acute Toxicity of American Ginseng Ultrafine Powder Based on Microbial Diversity
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Abstract:
The anti-fatigue effect and acute toxicity of American ginseng ultrafine powder on mice were studied, and the potential mechanism of action was explored. The mice in each group were administered with continuous intragastric administration for 31 days. The body weight, behavioral index, biochemical index and intestinal microbial changes were measured during and after the administration. Compared with the blank group, the time of the rod, the running distance and the climbing time of mice in the American ginseng ultrafine powder group were prolonged, which were 31.03%, 15.67%, and 27.77%, respectively; hepatic glycogen and muscle glycogen, skeletal muscle ATP were increased by 35.78%, 29.29%, and 14.49%, respectively. The levels of MDA and BUN in serum were significantly decreased by 24.03% (p<0.05) and 13.27% (p<0.01), respectively, and T-SOD activity was increased by 12.71%. Ruminiclostridium_9 (p=0.0367) and Oscillibacter (p=0.0154) abundance decreased, and Turicisbacteria (p=0.0001) abundance increased. There was no obvious pathological change in HE in the gastrointestinal tract; 25.6 g/kg of ultrafine powder tablets were administered to KM mice within one day, and there was no significant change in body mass, behavior and gastrointestinal pathology. The results showed that the anti-fatigue effect of American ginseng ultrafine powder group was better than the other two modes of administration, which was directly related to increasing energy supply and reducing the accumulation of metabolic substances, and may be indirectly related to the change of intestinal flora; no acute toxicity to KM mice was observed.
