Effect of Vitamin D on Lipid Metabolism in Obese Rats
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Abstract:
The effect of vitamin D on lipid metabolism in obese rats was investigated. Obesity rat model was established. The rats were divied into normal group, model group, high dose group (2.40 μg/mL), medium dose group (1.20 μg/mL), low dose group (0.60 μg/mL) and orlistat group (0.10 mg/mL). The body weight, body length, Lee's index, epididymal fat pad mass and fat body mass index were evaluated. Total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and the morphology of rat adipocytes were detected. Peroxisome proliferator-activated receptor gamma (PPAR-gamma), leptin and mitochondrial uncoupling protein (UCP) protein expression were also detected. The weight of rats, Lee's index, the weight of epididymal fat pad, fat body mass index, TC, TG, LDL-C and HDL-C in high dose group were 250.76 g, 2.52%, 5.05 g, 1.41 g, 1.96 mmol/L, 0.83 mmol/L, 1.05 mmol/L (lower than that in model group), and 0.59 mmol/L (higher than that in model group, p<0.05), respectively. The expression of PPAR-gamma and leptin in the high dose group was lower than that in the model group, and the expression of UCP in the high dose group was higher than that in the model group (p<0.05). Vitamin D can improve lipid metabolism in rats by regulating the expression of PPAR-gamma, leptin and UCP.
