Ameliorating Effect of Bifidobacterium longum DD98 on Type 2 Diabetes and Obesity in Mice
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
The ameliorating effects of Bifidobacterium longum DD98 on high fat diet-induced type 2 diabetes mice and obesity in mice were investigated. Type 2 diabetes experiments: C57BL/6N mice were randomly divided into four groups (6 rmice per group): the normal chow group given a normal chow diet; the model control group, Bifidobacterium longum DD98 intervention group, and blank culture medium intervention group fed a high-fat diet. After four weeks, model mice with diabetes was established using streptozotocin (STZ). The mice were given the tested samples for 3 weeks, before glucose tolerance test and measurements of various indicators. Compared with the of the model group and the blank culture medium intervention group, the DD98 intervention group had a significantly decreased fasting blood-glucose (FBG) (18.66±1.84 mmol/L), along with significantly improved glucose tolerance and reduced serum/liver total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels. Obesity experiments: C57BL/6N mice were randomly divided into four groups (6 rmice per group): the normal chow group given a normal chow diet; the model control group, Bifidobacterium longum DD98 intervention group, blank culture medium intervention group with a high-fat diet. After five weeks of treatments, various indicators were measured. Compared with the high-fat diet group and the blank culture medium intervention group, the DD98 group had significantly lowered fasting body weight (20.89±2.51 g) and serum/liver TC, TG and LDL-C levels with significantly reduced fat accumulation in the liver. Therefore, Bifidobacterium longum DD98 could effectively ameliorate the symptoms of type 2 diabetes and obesity, and further alleviate dyslipidemia caused by type 2 diabetes and obesity, and liver injury caused by obesity.
