Study on the Protective Effect of Zhige Oral Disintegration Tablets on Mice with Alcoholic Liver Injury
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Abstract:
Zhige oral disintegration tablets’ relieving effect on the hangover of drunken mice and hepatoprotective effect on mice with alcoholic liver injury were investigated. In anti-drunk study, after the model was established, 3 groups of mice were given intragastric intervention with high, medium and low dose of Zhige oral disintegration tablets, pure water was used as a control, and the time for the disappearance of righting reflex and recovery was recorded. In liver protection study, except the normal group was given pure water, the other groups were given 56-degree white spirits, and after 30 minutes, except thenormal group and the model group, the positive drug group and the high, medium and low dose groups were administered bifendate and Zhige oral disintegration tablets respectively for 10 consecutive days. The body weights of the mice were measured and their liver coefficients were calculated. The serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione (GSH content) in the liver tissues were measured. Compared with the model group, the drunken time and the hangover time of the mice in the high-dose group were prolonged by 6 min and 122.94 min (p<0.01), respectively. In the drug groups, the body weight of the mice increased and the liver mass indexes decreased to various degrees. Compared with the normal group, the model group’s serum ALT level increased by 99.8 IU/L, AST content increased by 48.03 IU/L, MDA of the liver tissue increased by 9.45 nmoL/L, and GSH content of the liver tissue decreased by 9.45 nmoL/mg, and SOD content was reduced by 51.13 U/mg (p<0.05). Compared with the model group, the high, medium and low dose groups’ serum MALT, AST and MDA content in liver tissue were reduced and liver GSH and SOD content (p<0.05) were increased, and the results were dose-dependent. It could be seen that Zhige oral disintegrating tablets were alcohol relieving and hepatoprotective.
