Optimization of β-cyclodextrin-maleate preparation using Response Surface Methdology
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Abstract:
Cyclodextrins are cyclic oligosaccharides possessing hydrophobic cavity, the cavity size and the inner hydrophobicity are suitable for encapsulating a variety of guests, which could improve the solubility of hydrophobic drug and protect the natural medicine. Some binding compounds could decrease β-cyclodextrin solubility in water, which limits its applications. In this study, the β-cyclodextrin-maleate (CDM) was prepared to improve solubility of β-cyclodextrin for application to food and drug industries. A response surface methodology was used to obtain a mathematical model that described the process and the optimal parameters were determined: the maleic acid 4.327 mmol, solid-to-liquid ratio 0.408, reaction temperature 109.462 ℃ and ethanol concentration 48.213%. Under these optimum conditions, the esteri?cation rate could be up to 40.977±2.032%, which was closed to the predicted value (40.71%). Moreover, the obtained product was characterized and identified by IR and MS.
