The Anti-fatigue Activities of Polysaccharides Extracted from the Agaricus Bitorquis (QuéL.) Sacc.Chaidam
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Abstract:
In order to study the anti-fatigue activity of the polysaccharides from Agaricus bitorquis (Quél.) Sacc.Chaidam, polysaccharides were extracted from the sporocarp, fermentation broth and mycelium of Agaricus bitorquis (Quél.) Sacc.Chaidam by hot water, respectively. Then mice were treated by intragastric administration with three kinds of polysaccharides at the dose of 100 mg/kg for 35 days. After last treatment, mice were forced to swim, and the forced swimming time and the changes of hemoglobin (Hb) level in mice blood, the blood urea nitrogen (BUN), lactate dehydrogenase (LDH) and lactic acid (LA) levels in mice plasma and the hepatic glycogen (HG) level were recorded. The results showed that there were three kinds of fractions in the polysaccharides sporocarp (PS), polysaccharides from fermentation broth (PFB) and polysaccharides from mycelium (PM). In the forced swimming test of mice, the swimming time of mice in PS group, PFB group and PM group were 1.93, 2.33 and 3.03 times higher than that of the control group (29.65±1.92 min), respectively, and the PS, PFB and PM not only could increase the Hb level in mice blood, HG level in mice liver and LDH level in mice plasma, but also could decrease the BUL and LA levels in mice plasma. The PM showed better effects than PS and PFB, and the levels of Hb in mice in mice blood, LDH, BUN, LA in mice plasma and HG in PM group were 2.19, 1.27, 0.26, 0.38 and 3.05 times higher, respectively, than that of control group (236.72±15.20 g/L, 9.95±0.32 Ku/L, 16.28±0.04 mmol/L, 17.61±1.29 mg/g, respectively). These results indicated that the PS, PFB and PM from Agaricus bitorquis (Quél.) Sacc.Chaidam performed the anti-fatigue activity, improving the exercise endurance and reliving fatigue in exercise, and that the PM showed better anti-fatigue activity than PS and PFB.
