Anti-aging Effect of Rhodiola on the HSF and HaCaT Cell
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Abstract:
The anti-aging effect of four extracts (saponins, flavonoids, polysaccharides and volatile oils) from Rhodiola was investigated using the anti-aging model with damaged human skin fibroblasts (HSF) and (Human immortalized keratinocytes) HaCaT cells irradiated by medium-wavelength UV. The results showed that the test four extracts exhibited a concentration-dependent anti-aging effect on HSF and HaCaT cells, with the decreasing activity in the order: saponins > polysaccharides > flavonoids > volatile oils. The anti-aging activity of saponins at 800 μg/mL was 2 times that of the control (Vc). Flavonoids and polysaccharides have the similar repairing effects on demaged HSF cell, which were better than volatile oils. In the case of the HaCaT cell, polysaccharides, flavonoids and volatile oils had the same anti-aging effects. Therefore, it could be concluded that different extracts of Rhodiola have an anti-aging ability to repair demaged human skin cell, which may provide a theoretical basis for the development of Rhodiola products with anti-aging and anti-radiation activities.
