Preventive Effect of Solid Beverage on Nutritional Obesity and Hyperlipidemia in Rat Fed with High-fat Diet
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Abstract:
Rats were fed with a high-fat diet and the preventive effect of solid beverage on nutritional obesity and hyperlipidemia was determined. After establishing an obesity model in sprague dawley male rats, the rats were randomly divided into six groups: high-, medium-, and low-dose (solid beverage feed accounted for 50%, 30%, 10% of total intake), basic, model, and positive group (simvastatin, 10 mg/(kg?d)). After four weeks of feeding, blood samples were withdrawn from the abdominal artery under anesthesia, and the following parameters were assessed in serum: triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the serum. Additionally, body fat weight was measured, and liver biopsy was also performed. The results showed that the model group showed significant (p<0.01) changes in weight, fat coefficient, liver, Lee's index, and liver index, which were higher than those found in the base control group, in addition to significantly lower food utilization, decreased serum TG, LDL-C, ALT, AST, and increased HDL-C compared with that in the model group. All groups fed with the solid beverage showed decreased serum TG, LDL-C, ALT, AST, and increased HDL-C, with significant (p<0.01) difference noted for the high-dose group. Thus, solid beverage can significantly inhibit body weight, reduce hyperlipidemia, protect the liver, and exert a preventive effect against obesity-related disease.
