Study on Colon-specific Delivery of β-carotene with Oat β-glucan Octenylsuccinate Micelles
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Abstract:
Polymeric micelles have broad potential applications in the fields of medicine, nutrition, food processing, and others owing to their capabilities to specifically deliver lipophilic active ingredients and enhancc their solubility. In this paper, oat β-glucan octenylsuccinate (OS-glucan) micelles were studied, and the colon-specific delivery of β-carotene using OS-glucan was preliminarily discussed. The study showed that in simulated gastrointestinal fluid, OS-glucan exhibited relatively small changes in particle size and polydispersity index (PDI), and the retention rate of loaded β-carotene was decreased. In simulated intestinal fluid, the partial structure of OS-glucan micelles was damaged, leading to some degradation. The content of β-carotene in the micelles was decreased, the particle size of micelles was significantly increased, and the PDI was also pronouncedly increased. During the in vitro colonic fermentation experiment, OS-glucan micelles disintegrated rapidly, and β-carotene was quickly released in seven hours. Therefore, OS-glucan micelles can be used as a carrier of β-carotene to effectively regulate the releasing behavior in simulated gastrointestinal fluid, and the colon-specific delivery of β-carotene can somewhat be achieved.
