Influence of Tryptophan on Amino Acid Transporter in Weaned Piglet
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Abstract:
Tryptophan (Trp) participates in the regulation of protein synthesis and plays very important roles in regulating appetite and maintaining health. The effect of Trp on amino acid transporters in weaned piglets was explored by determining growth performance, serum biochemical parameters, free amino acid content in the serum, tryptophan 2,3-dioxygenase (TDO) content in the liver, indoleamine 2,3-dioxygenase (IDO) content in the jejunum, and gene expression of amino acid transporters in weaned piglets. The results showed that addition of 0.2% Trp significantly increased the daily gain and daily feed intake, markedly elevated the levels of serum Trp and leucine, and dramatically decreased the levels of valine and isoleucine. The addition of 0.1% Trp and 0.2% Trp significantly increased TDO content in the liver and IDO content in the jejunum, respectively. The addition of 0.2% Trp markedly enhanced the gene expression of ATB0,+, 4F2hc, B0AT1, and ASCT2 in the jejunum (P < 0.05). In conclusion, Trp can promote the expression of amino acid transporter-related genes and ultimately promote the transport and uptake of amino acids, indicating that Trp can regulate and control the health of the body by upregulating the expression of amino acid transporters.
