Effect of Red Cabbage Anthocyanins in Regulating the Blood Lipid Profile of Atherosclerotic Rabbits
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Abstract:
In this study, the influence of red cabbage anthocyanins (RCAs) in regulation of the blood lipid profile of atherosclerotic rabbits was studied. New Zealand white rabbits were divided into normal control group, model control group, low-, medium-, and high-dose anthocyanin groups, and positive control (simvastatin) group (n = 8). The normal control group was fed an ordinary diet and the other groups were fed high-fat diet. After six weeks, the rats of the low-, medium-, and high-dose anthocyanin groups were administered 30, 60, and 90 mg/(kg?d) anthocyanin by gavage, respectively; the positive control group received 5 mg/(kg?d) simvastatin; and the model group received 2 mL/(kg?d) physiological saline. Serum total cholesterol (TC), triglycerides (TGs), and low-density lipoprotein (LDL-C) were measured after 6 and 10 weeks. After 10 weeks, the rabbits were sacrificed, and the aorta was collected for pathomorphological observation. Results showed that RCA and simvastatin significantly reduced serum TC, TGs, and LDL-C content in the rabbits. Histological sections demonstrated that RCA could mitigate atherosclerotic plaque and other atherosclerotic damages, demonstrating its important, protective, and dose-dependent effects on atherosclerosis and hyperlipidemia.
