A Graphene/Ionic Liquid Modified Screen-printed Electrode for Detection of Rutin in Medicine
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Abstract:
In this paper, a novel screen-sprinted electrode (GR-ILSPE) modified by n-octylpyridinum hexa?uorophosphate (OPFP) and graphene (GR) was fabricated and used for sensitive detection of rutin in medicine. The novel screen-sprinted electrode produced with low costs combined with good advantages of ionic conductivity, adhesiveness and electrochemical stability that existed at room temperature, and also with good performances of the large specific surface area, high electron transfer and catalytic ability of graphene that greatly enhanced the practical value and electrochemical properties. Different electrochemical methods such as cyclic vohammetry, impedance spectroscopy and differential pulse voltammetry were used to investigate the electrochemical behaviors of rutin on GR-ILSPE, and the electrochemical parameters were optimized. Under the optimal conditions, the oxidative peak current was linearly related to its concentration in the range from 5×10-8 to 5.5×10-6 mol/L with the detection limit estimated to 2.5×10-8 mol/L, and the linear regression equation was I (μA)= 1.01C(μmol/L) -0.024 (r=0.99). Finally, the developed electrode was successfully applied to detect the content of rutin in tablet, which displayed excellent selectivity and good stability.
