Effect of Smilax Glabra Formulated Preparation on the Hyperuricemia Induced by Potassium Oxonate
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Abstract:
The rat model of hyperuricemia was established by oral gavage with potassium oxonate, and the effect of a Smilax Glabra prescription on the hyperuricemia was studied. The rat model of hyperuricemia was established in accordance with 1.5 g/(kg?d) continuous intragastric dose by potassium oxonate for 30 d. When tested at the 15th and 30th d, serum uric acids in the model were significantly different to the normal control group, urea nitrogen and creatinine in the serum had no pathological change. After continuously oral gavage for 30 d with Smilax Glabra prescription (15th and 30th d tests), the serum uric acid and urea nitrogen were reduced in the corresponding model with different doses and the creatinine was significantly reduced with high doses. Therefore the Smilax Glabra prescription has a certain effect on potassium oxonate-induced hyperuricemia.
