Antioxidant and Antiproliferative Activities of 5-Hydroxymethylfurfural
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Abstract:
The antioxidant of 5-Hydroxymethylfurfural (5-HMF) was evaluated by ABTS, DPPH and hemolysis assay. In the hemolysis assay, the morphological changes of erythrocytes were observed directly by an environmental scanning electron microscope (ESEM). Meanwhile, MTT assay was carried out to investigate antiproliferative activities of 5-HMF. The results showed that the scavenging rates of ABTS and DPPH were 53.98 ± 0.016% and 17.80 ± 0.010%, respectively when using 5-HMF at 6.4 mM. And the emolysis inhibition rate reached 89.95 ± 0.001% at a concentration of 12.0 mM, suggesting that 5-HMF could inhibit the hemolysis oxidative damage induced by AAPH. The results was verified by observation of the morphological changes of erythrocytes using ESEM. 5-HMF showed a higher antiproliferative activity on human melanoma A375 cells than L02 cells and SW480 cells, which was certificated by inverted microscope.
