Effects of Coenzyme-Q10/Lycopene Single or Combination on Exercise Capacity of Rats
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Abstract:
This paper studied the effect of coenzyme Q10/lycopene alone or their combination on the exercise performance of induced fatigue rats. 48 rats were randomized into 4 groups. After 4 weeks of consecutive administration with the materials tested by gastric perfusion method, exhaustive swimming time was tested. After 24 hours rest, the SOD, MDA of liver/muscle tissues and the enzyme activity of CK/LDH in blood of each group were analyzed. Result showed that, compared with control group, coenzyme Q10/lycopene alone(P<0.05) or their combination（P<0.01) can prolong exhaustive swimming time. A significant decrease of MDA content in liver and muscle tissue was observed in mice administered combination group (P<0.05), and MDA reduction in liver of Q10 alone group was also observed (P<0.05). SOD activity in liver tissues revealed an obvious increase in mice with combined administration (P<0.01) and Q10 group (P<0.05) . The activity of LDH in blood exhibited a significant amelioration in mice with Q10 single(P<0.05) or combined administration (P<0.01). The CK in blood also got better result in mice with individual administration of Q10 (P<0.01) or lycopene (P<0.05), or combined administration(P<0.01). The result showed that individual administration of coenzyme-Q10 and lycopene can enhance the endurance of rats and improve the anti-oxidation capability. A synergistic effect among them is also achieved.
