阿魏酸（Ferulic Acid，FA）是一种来源于植物次生代谢的羟基肉桂酸类酚酸，在日常谷物中含量丰富，具有抗氧化、抗血栓、抗炎、抗肿瘤、保护内皮细胞的功能以及保护心血管系统等多种药理学活性。目前，FA及其衍生物已广泛应用于医药、食品添加剂等领域，对心血管疾病的治疗有重要作用。动脉粥样硬化（Atherosclerosis，AS）是一种复杂的慢性炎症疾病，是机体在脂质代谢失调、内皮细胞功能损伤的情况下，动脉壁处发生的纤维脂肪性病变，动脉因斑块的积聚而变硬，造成严重的血管功能障碍。中草药当归和川芎均对AS有治疗效果，而FA是其中的主要活性成分，研究FA对AS的抑制作用具有非常重要的现实意义，该研究就近年来FA在AS疾病方面的研究进展进行综述，主要介绍了FA抗AS的几种作用方式及其潜在机制，并从能量代谢的角度提出了FA激活棕色脂肪进而抑制AS的可能性。这将对FA在AS的预防及临床治疗中提供新的理论依据，以期提高FA在日常饮食中的生物利用度，为FA的进一步开发和应用提供参考。

Ferulic acid (FA) is a hydroxycinnamic acid derivative of phenolic. FA originates from the secondary metabolism of plants and is prevalent in daily grains. The variety of pharmacological activities of FA include anti-oxidation, anti-thrombosis, anti-inflammation, anti-tumor, endothelial cell protection, and cardiovascular system protection. FA and its derivatives are widely used in food additives and other applications, including treatment of treatment of cardiovascular diseases, such as atherosclerosis (AS). AS is a complex and chronic inflammatory disease characterized by fibrofatty lesions in the arterial wall under the conditions of lipid metabolism disorder and endothelial cell dysfunction. As leads to arterial hardening with the accumulation of plaques, resulting in serious vascular dysfunction. The Chinese medicinal herbs of Angelicae sinensis and Ligusticum chuanxiong Hort. have therapeutic effects on AS; FA is one of the main active components of these herbs. Therefore, studying the inhibitory effect of FA on AS is relevant and important. This article reviews recent advancements in research on the effects of FA on AS, mainly describing the various ways through which FA counteracts AS and its potential mechanisms. Additionally, from the perspective of energy metabolism, the article presents evidence suggesting the possibility that FA activation of brown fat inhibits AS. The findings summarized in this review could provide a new theoretical basis for the prevention and clinical treatment of AS with FA, suggest the increase of bioavailability of FA in daily diet, and provide a reference to further develop the therapeutic applications of FA.

国家自然科学基金青年科学基金项目（81900777）；国家自然科学基金-面上基金项目（32272306）