该文研究了含肽即食燕窝、常规炖煮燕窝唾液酸（Sialic Acid，SA）的消化、吸收与利用状况。8 w龄雄性SD大鼠32只，随机分为空白对照组（Blank Control，BC）、含肽燕窝组（Peptide-Containing Edible Bird's Nest，PB）、常规燕窝组（Traditional Edible Bird's Nest，TB）、唾液酸标准品组（SA Standard Control，SC），经口灌胃干预。连续2 d收集粪尿，检测唾液酸吸收量和储留量并计算消化、吸收率；连续60 d干预，监测血浆游离、蛋白结合唾液酸、红细胞膜唾液酸含量变化，通过唾液酸化程度评价利用状况。2 d粪尿监测尚未发现各组唾液酸消化、吸收率有统计学差异。连续60 d干预后，各干预组血浆游离唾液酸浓度、血浆蛋白结合唾液酸含量、红细胞膜唾液酸含量（P<0.005）均高于BC组；干预10 d时，PB组蛋白结合唾液酸含量比BC组提高36.36%（P<0.05），红细胞膜结合唾液酸比TB组、SC组提高28.13%和13.89%（P<0.05）。综上，血液的唾液酸化可以反映燕窝唾液酸的利用程度；肽类能促进唾液酸被机体更快速利用；长期食用各类燕窝均能有效提高机体唾液酸化水平且优于摄入游离唾液酸。

The digestion, absorption, and utilization of sialic acid (SA) in the ready-to-eat peptide-containing and the traditional stewed edible bird’s nest products were compared. Male SD rats aged 8 weeks (n=32) were divided into four groups randomly, including blank control group (BC), peptide-containing edible bird’s nest group (PB), traditional edible bird’s nest group (TB), and sialic acid standard control group (SC). After oral gavage, the feces and urine were collected over 2 days to evaluate the absorption and retention of SA by calculating its digestion and absorption rates. Blood was collected intermittently during 60-day consecutive gavage to monitor the content alteration of the free and protein-bound SA in plasma and the erythrocyte membrane-bound SA, and the degree of sialyation was adopted to evaluate exogenous SA utilization. The results of the 2-day feces and urine monitoring did not reveal any significant statistical differences in SA digestion and absorption among all groups. The results of 60-day consecutive gavage revealed that the free SA concentration (P<0.005) and protein-bound SA content (P<0.005) in plasma and the erythrocyte membrane-bound SA content (P<0.001) were significantly higher in each intervention group compared to the BC group. After 10 days of intervention, the protein-bound SA content in the PB group was 36.36% higher than that in the BC group (P<0.05), and the erythrocyte membrane-bound SA in the PB group increased by 28.13% and 13.89% compared to the TB and SC groups (P<0.05), respectively. In conclusion, the sialylation of blood can reflect exogenous SA utilization and peptides can promote the utilization of SA. Long-term consumption of all types of edible bird’s nests can effectively improve the sialylation level of the body, surpassing the benefits derived from the intake of free SA.