陈皮是传统中药材，药食两用，具有“理气健脾，燥湿化痰”等功效，富含黄酮类、挥发油类、生物碱类、柠檬苦素类、微量元素等。其活性成分以黄酮类化合物为主，具有多种药理活性，包括抗炎、抗氧化、抗血栓、抗菌、抗病毒、降血糖、降血脂等，被广泛应用到食品和保健品等诸多领域。但是由于黄酮类化合物溶解性差、生物利用率低，限制其应用，随着生物技术的不断发展，微生物转化黄酮以及其他活性物质已成为国内外研究热点。已有报道对陈皮的活性成分的结构特征、生物活性，以及陈皮中微生物及其转化黄酮类化合物进行了深入系统的研究。该研究综述了陈皮表面微生物及其转化黄酮类物质的研究进展，为微生物转化陈皮活性黄酮的开发及应用提供参考。

Citri reticulatae pericarpium is a traditional Chinese herbal medicine, which can be used as both medicine and food. It has functions related to the regulation of Qi and spleen strengthening, drying dampness and phlegm reduction. It is rich in flavonoids, volatile oils, alkaloids, limonoids and other trace elements. The flavonoids are the main active components, which exhibit a variety of pharmacological activities, including anti-inflammatory, anti-oxidant, anti-thrombotic, anti-bacterial, anti-viral, hypoglycemic and hypolipidemic effects. It has been widely used in many fields, such as food and healthcare products. However, the applications of flavonoids have been restricted due to their poor solubility and low bioavailability. With the continuous development of biotechnology, microbial transformation of flavonoids and other active substances has become a research hotspot domestically and abroad. It has been reported that the structural characteristics, biological activities of the active components of citri reticulatae pericarpium, as well as its microorganisms and their transformed flavonoids have been deeply and systematically studied. This article reviews the research progress of the microorganisms on the surface of citri reticulatae pericarpium, and their roles in the biotransformation of flavonoids, which provides a reference for the development and application of microbial transformation of active flavonoids from citri reticulatae pericarpium.

国家自然科学基金项目（31901713）；国家重点研发计划项目（2021YFD1600100）；广东省自然科学基金项目（2021A1515011049）；广东省现代农业产业技术体系创新团队建设项目（2020KJ110）；广东省扬帆计划引进创新创业团队项目（2017YT05H045）；广东省农业科学院人才项目（R2020PY-JX011）