随着社会经济发展，由营养过剩引起的肥胖、动脉粥样硬化性心脏病、高血压、糖尿病、痛风与癌症等营养相关疾病日渐严重，已成为威胁人类健康的重要公共卫生问题。而其中的心血管疾病是造成全世界死亡率提高的首要原因。目前，针对心血管疾病的独立危险因素，已有大量降脂产品涌入市场，但大部分由于副作用或降脂效果不明显而达不到预期效果。近年来，人们密切关注和研究膳食多酚（polyphenols），已表现出其广阔的开发前景。多酚类化合物是所有酚类衍生物的总称，广泛分布于植物界，尤其是深色水果、蔬菜和谷物，具有多方面保健和药理作用。本文从机体脂肪代谢、脂肪细胞演化、肠道微生物等方面介绍了膳食多酚的降脂机理研究进展。为进一步研究膳食多酚和降脂机理提供参考。

With the development of society and economy, the nutrition-related diseases such as obesity, atherosclerotic heart disease, hypertension, diabetes, gout and cancer caused by excessive nutrition are increasingly serious, which have become an important public health problem threatening human health. Cardiovascular disease is the leading cause of increased mortality worldwide. At present, a large number of lipid-lowering products have flooded into the market aiming at independent risk factors of cardiovascular diseases, but most of them fail to achieve the expected effect due to side effects or inconspicuous effect of lipid-lowering. In recent years, people pay close attention to polyphenols and conduct research on them. Dietary polyphenols are the general name of all phenolic derivatives. They are widely distributed in the plant world, especially in dark fruits, vegetables and grains. They have many health and pharmacological effects. In this paper, the research progress of lipid lowering mechanism of dietary polyphenols was introduced from the aspects of body fat metabolism, fat cell evolution and intestinal microorganismto provide reference for further study on dietary polyphenols and lipid lowering mechanism.

海南省重大科技计划项目（ZDKJ2016003）；湖南省科技创新计划项目（2017SK2430）