本文使用了有机-无机杂化的方法制备了对甲基对硫磷具有特异性识别能力的纳米二氧化硅表面分子印迹材料。该方法使用丙烯酰胺作为功能性单体，KH-570硅烷作偶联剂，甲基对硫磷作为模板剂，以氨基修饰的纳米二氧化硅作为载体在氯仿溶液中进行表面的分子印迹嫁接。通过溶剂与功能性单体的作用，氨丙基功能性单体不仅能选择性地在硅材料表面发生聚合，还能作为一种辅助性地单体驱使模板剂进入到已形成的壳层结构中，从而产生有效的特异性识别位点。制备出的MIPs-SiO2纳米颗粒具有三维的核壳结构以及大的比表面积。分子印迹后的壳层结构为甲基对硫磷分子提供了丰富的识别位点，使其对模板剂具有强的选择性吸附能力。以MIPs-SiO2纳米颗粒作为一种固相分散萃取吸附剂的载体，可以选择性地萃取梨子及其他绿色蔬菜的样品中微量的甲基对硫磷，并且能够获得84.7~94.4 %的回收率。

Hybrid organic-inorganic surface imprinted silica nanoparticles for specific recognition of methyl parathion was prepared by molecular imprinting technique, We molecularly imprinted silica nanoparticles in chloroform by using amino modified silica nanoparticles as the supports, acrylamide as the functional monomer, γ-methacryloxypropyl trimethoxy silane as the grafting agent, and methyl parathion as a template. The amino propyl functional monomer could not only selectively polymerize on silicon surface, but also as an assistive monomer to drive the template agent into the formed shell structure to produce effective specific recognition sites. The resultant MIPs-SiO2 nanoparticles display a three-dimensional core-shell structure and a large surface area. The molecularly imprinted polymer shell structure provided recognition sites for methyl parathion, making it have a strong selective adsorption capacity for the template, Traces of methyl parathion were selectively extracted from green vegetable and pear samples using MIPs-SiO2 nanoparticles as the sorbents of solid-phase dispersion extraction with recoveries of 84.7~94.4%.