[关键词]
[摘要]
共结晶技术是精细化学品、制药等高附加值行业的前沿研究方向。本文以赤藓糖醇为载体,采用熔融共结晶法制备了赤藓糖醇-三氯蔗糖固态复配产品,应用TG-DSC、XRD和SEM等对其结构与性能进行了表征分析;结果表明:熔融共结晶法制备的赤藓糖醇-三氯蔗糖固态复配产品为共晶体,赤藓糖醇-三氯蔗糖共晶体的DSC热分解吸热峰的峰顶温度为156.2 ℃,而三氯蔗糖的热分解吸热峰的峰顶温度为134.4 ℃,说明共结晶过程有效提高了共晶体复配产品中三氯蔗糖的热稳定性,共结晶试验中发现晶种加入量和晶种粒度分布是影响赤藓糖醇-三氯蔗糖共结晶产品粒度分布和堆密度的重要因素;当加入晶种的粒度为120~200目,加入量为10 wt%时,熔融共结晶法制备的赤藓糖醇-三氯蔗糖共晶体产品中30~60目的晶体占总质量的91.8%,堆密度可达0.82 g/cm3。
[Key word]
[Abstract]
Co-crystallization technologies have been known as the leading edge in the fine chemicals and pharmaceuticals industries. The melt co-crystallization process was adopted to produce the solid recombination product of meso-Erythritol and sucralose, the structure and properties of which had been characterized and analyzed by using TG-DSC, XRD, and SEM. The results indicated that the solid recombination product of meso-Erythritol and sucralose is a co-crystal. The endothermic peak temperatures of the thermal decomposition of the co-crystals and pristine sucralose were found to be 156.2 ℃ and 134.4 ℃, respectively,indicating co-crystallization enhanced the thermal stability of sucralose . Seeding load and crystal size distribution (CSD) of the seeds were found to have significant effects on the CSD and bulk density of the co-crystal products of meso-Erythritol and sucralose. When the process parameter of the co-crystallization of meso-Erythritol and sucralose was a seeding load of 10 wt% with CSD of 120~200#, the co-crystal products with 30~60# accounted for 91.8% of the whole product crystals, and its bulk density was 0.82 g/cm3.
[中图分类号]
[基金项目]
湖北省大学生创新创业训练计划项目(201410488034)