本文采用预防性高血脂动物模型实验方法考察雪莲果中提取多糖的降血脂活性。分别对小鼠的体重，血清总胆固醇(TC)，三酰甘油(TG)，低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）进行了测定。结果发现：雪莲果多糖对小鼠体重增长无显著性影响；雪莲果粗多糖和纯多糖极显著降低高血脂小鼠血清TC、TG和LDL-C含量（p<0.01）；雪莲果纯多糖显著提高小鼠血清中HDL-C含量（p<0.05），并且纯多糖能极显著降低小鼠肝脏TG和TC含量（p<0.01）。表明雪莲果中糖类成分对高脂饮食所致小鼠血脂升高有明显抑制作用，且纯多糖的效果优于粗多糖，能有效预防高血脂症。采用小鼠高血糖模型降糖实验方法考察雪莲果多糖的降血糖活性。结果显示：雪莲果粗多糖低、中剂量组空腹血糖值显著降低（p<0.05），证明雪莲果多糖体内降血糖效果。

An animal model of preventive hyperlipidemia was used to investigate the hypolipidemic activity of polysaccharides extracted from yacon. Body weight and the levels of serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured in mice with or without yacon polysaccharide treatment. The results showed that polysaccharides from yacon had no obvious effect on mouse body weight. The crude polysaccharides and pure polysaccharides remarkably decreased the serum TC, TG, and LDL-C levels in hyperlipidemic mice (p<0.01). Pure polysaccharides clearly increased the serum HDL-C levels (p<0.05) and the hepatic TG and TC levels (p<0.01) in mice. The results showed that the polysaccharides from yacon clearly inhibited the blood lipid level elevations caused by a high fat diet, and the pure polysaccharides had better effect than the crude polysaccharides. Additionally, the hypoglycemic activity of yacon polysaccharides was investigated using a mouse model of hyperglycemia. The result showed that the low- and medium-dose groups of crude polysaccharides from yacon decreased fasting blood glucose levels significantly (p<0.05), demonstrating that the polysaccharides from yacon have a hypoglycemic effect in vivo.

国家星火计划重点项目（2015GA610001）；天津市农业科技成果转化与推广项目（201502180）