研究食品包装纸中饱和烃矿物油（MOSH）向食品模拟物Tenax的迁移，考虑了不同类型包装纸在不同温度下（25 ℃、40 ℃、100 ℃）的迁移行为，并采用毒理学关注阈值（TTC）的方法对MOSH进行安全评估。结果表明：温度一定时，厚度和克重是影响食品包装纸中MOSH迁移的重要因素，厚度和克重越小，MOSH的迁移率越大；在一定条件下，温度越高，MOSH达到迁移平衡的时间越短（100 ℃，100 min；25 ℃，8 d），迁移率越大（100 ℃，24.81%；25 ℃，7.82%）。所测定的包装纸中MOSH达到迁移平衡时的迁移量，都明显超过了JECFA规定的特定迁移量0.6 mg/kg，容易发生迁移的MOSH主要集中在C16~C18和C23~C26，均属于容易在人体内蓄积的中低粘度矿物油。TTC评估结果表明：主要发生迁移的MOSH烃类经Cramer分类均属于Class I，从四种食品包装纸中迁移到Tenax的MOSH，估计每日摄入量（EDI）均明显高于对应的TTC阈值（1.8 mg/person?day），需要引起关注。

The migration of mineral oil saturated hydrocarbons (MOSH) from food packaging paper into the food simulant Tenax was studied and the migration behavior of MOSH was explored for different types of food packaging paper and at different temperatures (25 ℃, 40 ℃, and 100 ℃). The threshold of toxicological concerns (TTC) was introduced to assess the safety of MOSH. The results showed that the thickness and grammage of the food packaging paper was important for the migration of MOSH at a specific temperature, and a smaller thickness and lower grammage led to a greater MOSH migration rate. Under certain conditions, a higher temperature resulted in a shorter time to reach the migration equilibrium for MOSH (100 ℃: 100 min; 25 ℃: 8 days) and a greater migration rate (100 ℃, 24.81% and 25 ℃, 7.82%). The amount of migrated MOSH of all testing packaging paper samples at equilibrium were beyond the migration limit (0.6 mg/kg) specified by the Joint FAO/WHO Expert Committee on Food Additives. Most MOSH is prone to migration had chains of C16~C18 or C23~C26, and they belonged to the low- and medium-viscosity mineral oils that are easily accumulated in the human body. The TTC results showed that migrating MOSH were classified as Cramer Class I. The estimated daily intakes of MOSH from four types of food packaging paper into Tenax were markedly higher than the corresponding TTC threshold (1.8 mg/person?day), which requires further analysis.

国家质检总局科技计划项目（2014IK078）；国家自然科学基金（21277061）