采用超声技术辅助提取玉米须水溶性成分，测定玉米须水提物的DPPH•、•OH清除能力和还原力等抗氧化作用，并通过小鼠实验，分析小鼠体质量、血清尿酸（Serum Uric Acid，SUA）、小鼠肾脏病理学观察，研究玉米须水提物对高尿酸血症小鼠的降尿酸作用。实验结果显示，玉米须水提物（C3组）具有显著的DPPH•（90.75%）、•OH清除能力（86.29%）和还原力（P<0.05），表明玉米须水提物具有巨大的抗氧化潜力。通过连续4周灌胃玉米须水提物，高尿酸血症小鼠体质量得到改善、SUA水平降低以及肾脏组织状态转好，其中玉米须水提物高剂量组（High Corn Silk Water Extract Group，HCS）小鼠SUA水平显著降低至726.26 μmol/L（P<0.05），脏器指数改善（0.60%），肾脏组织改善情况明显。因此，玉米须水提物具有较好的抗氧化和降尿酸活性，具有开发成为预防氧化损伤、高尿酸血症食品的市场潜力。

Ultrasound-assisted extraction (USE) was used to extract the water-soluble components of corn silk, and the resulting corn silk water extract (CSWE) was tested for DPPH• and OH• radical scavenging activities and subjected to reducing power evaluation. In addition, the uric acid-lowering effects of CSWE were investigated through mouse experiments, where the body weight, serum uric acid (SUA) levels, and kidney pathologies of the mice were observed. CSWE (C3 group) exhibited significant DPPH• and OH• activities (90.75% and 86.29%, respectively) and reducing power (P<0.05), indicating that CSWE has immense antioxidative potential. Four weeks of gavage with CSWE decreased the body weight and SUA levels and improved the kidney tissue health of hyperuricemic mice. The high CSWE (HCS) group in particular, showed significant improvements in their SUA levels (decreased to 726.26 μmol/L, P<0.05), organ indices (0.60%), and kidney tissue health. Therefore, CSWE has outstanding antioxidant and uric acid-lowering activities, and it could potentially be marketed as a functional food for preventing oxidative injury and hyperuricemia.

浙江省教育厅一般项目（Y201942135）；浙江省自然科学基金（LQ21C200004）