本文研究了丁香酚/淀粉包合物冻干粉的制备工艺，以提高它在医药领域应用中的稳定性、准确给药。选用莜麦的淀粉对丁香酚进行包合，采用超声法研究了丁香酚-淀粉包合物冻干粉的制备工艺。以包合率为考察指标，高效液相法测定包合物中丁香酚的含量，通过单因素试验考察了投料比、超声温度、超声时间对包合物制备效果的影响。进一步运用正交试验研究确定了丁香酚-淀粉包合物冻干粉的最佳工艺条件为：投料比为10:0.8，超声温度为50 ℃、超声时间为50 min，包合率为44.54%。影响包合率的因素顺序为：超声温度>投料比>超声时间。验证试验表明，通过扫描电子显微镜（SEM）、傅里叶红外色谱法（FT-IR）以及核磁共振（NMR）对制备的丁香酚/淀粉包合物冻干粉进行了鉴定，证明了丁香酚/糊化淀粉包合物冻干粉的形成。综上，采用超声法制备丁香酚/淀粉包合物冻干粉，经验证丁香酚/淀粉包合物冻干粉形成，通过正交实验优化制备工艺后，其包合率可达到44.54%。

The preparation technology of eugenol / starch inclusion compound freeze-dried powder was studied to improve its stability and accuracy in the application of medicine. The starch of naked oats was selected to encapsulate eugenol, and the preparation technology of the freeze-dried powder of eugenol starch inclusion compound was studied by ultrasonic method. The content of eugenol in the inclusion complex was determined by HPLC with inclusion rate as the index. The influence of the material ratio, ultrasonic temperature and ultrasonic time on the preparation of the inclusion complex was investigated by single factor test. The optimum technological conditions of the freeze-drying powder of eugenol starch inclusion compound were determined by the orthogonal test: the ratio of feeding materials was 10:0.8, the ultrasonic temperature was 50 ℃, the ultrasonic time was 50 minutes, and the inclusion rate was 44.54%. The order of influencing factors is: ultrasonic temperature>feeding ratio>ultrasonic time. The validation test for the preparation of eugenol/starch inclusion complex lyophilized powder was carried out by SEM, FT-IR and NMR The formation of eugenol/gelatinized starch inclusion complex freeze-dried powder was identified. In conclusion, the ultrasonic method was used to prepare eugenol/starch inclusion complex freeze-dried powder. The formation of eugenol/starch inclusion complex freeze-dried powder was verified. After the orthogonal experiment optimization of the preparation process, the inclusion rate reached 44.54%.

内蒙古自治区自然科学基金面上项目（2020MS08117）；内蒙古自治区蒙医药协同创新中心科研项目（MYYXT201910）；内蒙古医科大学科技成果转化项目（YKD2019CGZH001）；内蒙古医科大学人才发展团队（NYTD-2018014）；内蒙古自治区青年科技英才（NJYT-17-B29）