目前，乳及乳制品的品质已成为企业未来消费推广的核心竞争力，其中食品添加剂与非法添加物、农兽药残留、塑化剂等外源性风险物质是社会关注的焦点。因此，建立乳及乳制品中外源性风险物质筛查分析方法具有重要的现实意义和应用价值。但乳及乳制品成分复杂，外源性风险物质又大多为小分子物质，含量低，不易检测。因此要求仪器具有很高的选择性与超高的质量精度。高分辨质谱可在复杂背景中对痕量成分(mg/kg、μg/kg)进行定性定量分析，并且能够同时测定上百种化合物，极大地提高了检测效率，符合乳及乳制品中外源性风险物质筛查分析的仪器需求。本文主要针对高分辨质谱在乳及乳制品中外源性风险物质筛查分析中的应用做具体阐述，并对其应用前景进行简要分析。

In recent years, the quality of dairy products has become the core competitiveness of enterprises in the future promotion of consumption. Food additives and illegal additives, residues of pesticides, veterinary medicine, plasticizer and other exogenous risk substances have caused widespread public concern. Therefore, it is of great practical significance and application value to establish screening methods of unknown exogenous risk substances in milk and dairy products. Milk and dairy products have complex components, while exogenous hazardous materials are mostly small molecules and have low contents. Therefore, they require high selectivity and high quality accuracy. High-resolution mass spectrometry allows the qualitative and quantitative analysis of trace components (mg/kg, μg/kg) in complex backgrounds, and it can measure hundreds of compounds at the same time, which greatly improves the detection efficiency. So the high-resolution mass spectrometry meets the demand of instruments for the screening of exogenous risk substances in milk and dairy products. This paper reviews the advantages and applications of high-resolution mass spectrometry screening of exogenous risk substances in milk and dairy products, and the prospective of its future application.

陕西省教育厅科研计划项目资助（17JK0112）；国家自然基金项目（31501443）