本文研究了18α、18β-甘草酸单体抗酒精性肝损伤作用。SD大鼠随机分为4组，分别为正常组，模型组，18α-甘草酸组，18β-甘草酸组。除正常组外，各组灌胃给予40%酒精，给药组分别灌胃给予18α-甘草酸和18β-甘草酸，每天给药一次，持续4周。于第4周，进行口服葡萄糖耐量实验（OGTT）。给药结束后，将所有大鼠麻醉处死，检测血清和肝脏中的生化指标，并进行肝组织病理学观察。与模型组相比，18α-甘草酸和18β-甘草酸单体对肝功能及抗氧化指标均有显著性改善作用；18β-甘草酸对糖、脂质、蛋白质的代谢具有显著性调控作用；病理切片结果显示，18α-甘草酸和18β-甘草酸均对肝细胞具有较好的保护作用。因此，18α-甘草酸和18β-甘草酸单体对酒精性肝损伤均有较好的保护作用，其中18β-甘草酸在调节糖、脂质及蛋白质代谢方面的作用优于18α-甘草酸。

The protective effect of 18α-glycyrrhizic acid and 18β-glycyrrhizic acid on the alcohol liver injury was investigated in this study. The SD rats were randomly divided into four groups: normal control group, model control group, 18α-glycyrrhizic acid group and 18β-glycyrrhizic acid group. Except for the normal group, each group was administered intragastrically with 40% alcohol, and the administration group was administered intragastrically with 18α-glycyrrhizic acid and 18β-glycyrrhizic acid once daily for 4 weeks. At the end of the 4th week, an oral glucose tolerance test (OGTT) was performed. After the administration, all rats were sacrificed, and the blood and liver samples were collected for the detection of biochemical index, liver function, and liver histopathology. Compared with model group, 18α-glycyrrhizic acid and 18β-glycyrrhizic acid had significant effects on improving liver function and antioxidant indexes. Moreover, treatment with 18β-glycyrrhizic acid significantly improved the metabolism of glucose, lipid and protein. The results of pathological sections showed that 18α-glycyrrhizic acid and 18β-glycyrrhizic acid all had better protective effects on hepatocytes. Therefore, 18α-glycyrrhizic acid and 18β-glycyrrhizic acid had good protective effects on the alcoholic liver injury, among which 18β-glycyrrhizic acid was superior to 18α -glycyrrhizic acid in modulating metabolism of glucose, lipid and protein.

河北省自然基金项目（H2013201203）；河北大学医学学科专项资金建设项目(2014A1003)资助；河北大学研究生创新资助项目（X201737）；河北大学实验室开放项目（sy201669）