为了探讨猪油、植物油及其调和油对血脂、肝脂及血尿酸的影响，评估其对特殊人群的健康潜在风险，本文研究以小鼠为模型，模拟居民用油习惯，将50只8周龄雄性C57BL/6J小鼠随机均分为葵花籽油组（SSO）、豆油组（SO）、猪油组（LO）、葵花籽油与猪油调和油组（SSO-L）、豆油与猪油调和油组（SO-L）5组，模拟我国部分人群（5%~10%）日均烹调油脂高摄入水平（95 g/d），每组日粮中分别添加10.5%的不同油脂，饲喂8周后采集血液和肝脏组织，检测血清和肝脏指标。结果显示，相比于其他各组，LO组在体脂和血脂方面都有显著或极显著升高（p<0.05，p<0.01）。而SSO-L组和SO-L组在肝脂方面显著高于对应的SSO组和SO组（p<0.05）。同时，SSO-L组和SO-L组的SUA和肝脏XOD水平都显著高于LO组（p<0.05）。表明在95 g/d的膳食油脂摄入水平下，猪油会极大增加肥胖和患脂肪肝病的风险。葵花籽油与猪油调和油和豆油与猪油调和油也会通过升高尿酸水平来增大痛风和脂肪肝的患病风险。此外，长期以该水平摄入这两种调和油对肝脏功能也有明显损伤。在该摄入水平下，豆油为较优选择。

In order to investigate the effect of lard oil, vegetable oil and their blend oil on the blood lipid, liver fat and blood uric acid, in addition to assess the potential health risks for a particular population, the mice were used as a model to simulate the dietary habits of residents. Fifty of 8 weeks old male C57BL/6J mice were randomly divided into 5 groups as follows: sunflower seed oil group (SSO), soybean oil group (SO), lard oil group (LO), blend oil of lard and sunflower seed oil (SSO-L), blend oil of lard and soybean oil group (SO-L group), respectively. They were fed with 10.5% of different oils for simulating high daily average cooking oil intake (95 g/d) in the part of Chinese people (5%~10%). After 8 weeks, the blood and liver tissues were collected to measure serum and liver indexes. The results showed that compared with other groups, LO significantly increased the body fat rate and blood lipid levels (p < 0.05 and p < 0.01). SSO-L and SO-L significantly increased the liver fat compared with the corresponding SSO and SO, respectively (p < 0.05). At the same time, SUA and hepatic XOD levels in SSO-L and SO-L groups were significantly higher than those in LO group (p < 0.05). The result suggested that the lard oil could greatly increase the risk of obesity and fatty liver disease at a dietary oil intake of 95 g/d. The blend oil of lard and sunflower seed oil or soybean oil could also increase the risk of gout and fatty liver disease by raising the level of uric acid. In addition, the long-term intake of these two kinds of blend oil at this level also had obvious damage to the liver function. At this level of intake, soybean oil was a better choice.

湖南省创新创业技术投资项目“低胆固醇无抗安全猪肉产业化关键技术集成创新与示范”（湘科发〔2017〕159号，项目编号：2017GK5009）