本文研究了青钱柳水提物（ACP）对糖尿病肾病（DN）大鼠脂代谢、血凝、纤溶和脂质过氧化的影响。以高脂高糖饮食加小剂量STZ诱导DN大鼠模型，随机分为模型组、二甲双胍组（0.20 g/kg/day）和低、中、高ACP给药组（0.05，0.10，0.15 g/kg/day）。药物干预8周，观察大鼠一般状态，记录血糖、尿蛋白变化，试验结束后，测定血清血脂指标、血浆血凝和纤溶指标以及肝脏脂质过氧化指标。实验表明：ACP给药组能显著降低DN大鼠血糖、尿蛋白以及TC、TG、LDL-C、FFA，D-Dimer、PTA和MDA含量（p＜0.05），其中TG最高降幅58.03%；显著提高HDL-C，PT、APTT、TT、FIB、INR、PT-R、APTT-R 、T-AOC、SOD、GSH-Px和CAT水平（p＜0.05），其中PT最高升幅74.60%；且各指标与血糖值相关，FFA与血糖显著相关（r=0.9990）。提示ACP对试验性DN模型大鼠具有降血脂、抗脂质过氧化、抑制高凝状态、活化纤溶系统从而保护肾功能的作用。

College of Pharmacy, Weifang Medical University, Weifang 261053, China) (2. Department of Basic Medicine, Weifang Medical University, Weifang 261053, China) Abstract: The aim of this study was to investigate the effect of aqueous extracts from Cyclocarya paliurus leaves (ACP) on hyperlipidemia, hypercoagulability, fibrinolysis and lipid peroxidation in diabetic nephropathy (DN) rats. High fat and sugar diet and a low dose of STZ were used to induce the DN rat model. Then the animals were divided into five groups: model, metformin, and three doses of ACP（0.05，0.10，0.15 g/kg/day）groups. General status, body weight, blood glucose, urine output and urine protein were recorded after intragastric administration. The indicators of blood fat in serum; blood coagulation and fibrinolysis in plasma and lipid peroxidation in liver were measured. The results showed that the levels of blood glucose, urine protein, TC, TG, LDL-C, FFA, D-Dimer, PTA, MDA were decreased significantly (P<0.05) with the highest decreasing rate of 58.03%, while the levels of HDL-C, PT, APTT, TT, FIB, INR, PT-R, APTT-R, SOD, GSH-Px, CAT, T-AOC were increased significantly (P<0.05) with the highest increasing rate of 74.60%. These indicators were correlated with the level of blood glucose well and FFA in particular(r=0.9990). This research suggested that ACP could regulate lipid metabolism, ameliorate hypercoagulability and the lipid peroxidation in DN rats.

国家自然科学基金资助项目（81274049）；潍坊医学院科技创新基金项目（K1302024）；山东省中医药科学技术研究项目（2015-231, 2015-235）