玉米赤霉烯酮（Zearalenone，ZEN，ZEA）是由镰刀菌属产生的一类具有类雌激素生物活性的霉菌毒素，广泛存在于玉米、小麦等谷物及其制品中。本文综述了各类微生物降解ZEN的研究现状，重点比较其脱毒效率及产物毒性，尤以不动杆菌（Acinetobacter sp. SM04）、粉红粘帚菌（Gliocladium roseum IFO 7063）、毛孢子菌（Trichosporon mycotoxinivorans）和假单胞菌（Pseudomonas sp. ZE -1）研究较为全面，进一步总结了ZEN降解的关键酶及其作用机制，为微生物降解玉米赤霉烯酮的研究提供依据，也为大环内酯化合物和芳香族化合物的降解开拓更广泛的途径。

Zearalenone (ZEN, ZEA) is an oestrogenic mycotoxin produced by a variety of Fusarium fungi, which contaminate cearal, such as corn, wheat and their derivates. This paper reviews the development status of various microorganisms degrading ZEN, focusing on detoxifying efficiency and toxicity of the products, especially Acinetobacter sp. SM04, Gliocladium roseum IFO 7063, Trichosporon mycotoxinivorans and Pseudomonas sp. ZEN-1 being comprehensively researched. Then it summarizes the key enzymes and action mechanisms of ZEN degrading, which lays a foundation on researches of microbial degradation of zearalenone, and also develops a broader way to the degradation of microlide and aromatic compounds.

国家自然科学基金（31201330）；广东省教育厅学科建设科技创新重点项目（2012CXZD0009）；华南理工大学青年教师基金（E5090620）