采用高效液相色谱法测定南海海域多种水产品中软骨藻酸（DA）的含量。样品粗提液通过LC-SAX强阴离子柱固相萃取净化，在乙腈-0.1%三氟乙酸水溶液（体积比为19:81）流动体系下进行定性分析，以外标法进行定量。结果表明，DA在1 mg/L~25.0 mg/L范围内有良好的线性关系，R=1.0，平均回收率为95.3%；11批次样品中有9批次被检出有DA累积，扇贝和钝齿短桨蟹中的DA累积较高，分别为10.113 μg/g和18.202 μg/g。

The contents of domoic acid (DA) poisoning in various aquatic products from South China Sea were detected by HPLC. The samples were firstly purified with LC-SAX (strong anion exchange)-SPE (solid phase extraction) and eluted with the mobile phase of acetonitrile-0.1% trifluoroacetate acid (19:81) using external standard method. A good linear range was found within 1-25.0 mg/L (r=1.0). The average recovery was 95.3%. And DA accumulation was detected in nine of the eleven samples. Higher DA accumulation was found in Chlamys farreri and Thalamita crenata, being of 10.113 μg/g and 18.202 μg/g respectively.