NO供体缓释系统的开发及其在食品保鲜中的应用研究进展

Research progress on the Development of NO Donor Sustained-release Systems and Their Applications in Food Preservation

摘要:

一氧化氮（Nitric Oxide, NO）因其突出的抗菌、抗生物膜和抗病虫害特性，在食品领域展现出优异的保鲜功能。为了进一步提高其稳定性、延长使用寿命、降低毒副作用，大量研究者正致力于开发稳定性更好、效率更高和安全性更强的NO供体缓释载体和系统。不同的缓释方式实现了NO的释放速率可在0.1~10 μmol/h之间变化，且释放时间可从数小时延长至数十天，这种增强的释放效应使得NO供体缓释系统在生物医学领域得到了广泛应用。该文综述了NO的产生和信号途径，并分析和总结了不同类型NO供体缓释体系的设计与开发及其在肉类、水产品、水果和蔬菜等食品保鲜领域中的实际效果和应用潜力。NO供体缓释体系的开发，可为增强NO的生物利用度以及为提高食品的品质和延长其货架期提供新的思路与解决方案，并在食品领域展现出巨大的应用前景。

Abstract:

Nitric Oxide (NO) has demonstrated excellent preservation function in the food field due to its outstanding antimicrobial, anti-biofilm and anti-pest properties. In order to further improve its stability, extend its service life, and reduce its toxic side effects, many researchers are dedicated to the development of NO donor sustained-release carriers and systems that are more stable, efficient, and safe. Different sustained-release strategies have facilitated the modulation of NO release rates within a range of 0.1 to 10 μmol/h, while extending the release duration from several hours to several tens of days. This enhanced release profile has enabled the widespread application of NO donor sustained-release systems in the biomedical field. In this paper, the production and signaling pathways of NO are reviewed. The design and development of various types of NO donor sustained-release systems, as well as their practical effectiveness and application potential in food preservation across categories such as meat, seafood, fruits and vegetables, are analyzed and summarized. The development of NO donor sustained-release system can provide new ideas and solutions to enhance the bioavailability of NO, improve the food quality and extend its shelf life, which shows great application prospects in the food sector.