植物源类黄酮对脂代谢重编程调控慢性肠道炎症的研究进展

The role of metabolic reprogramming in the development and development of chronic intestinal inflammation and the regulatory potential of natural flavonoids

摘要:

随着经济社会的发展,人们从单一的饮食习惯再到现在多样的饮食习惯,肠道的负担日益增加,导致慢性肠道炎症(IBD)患者数量逐年攀升。IBD是一类病因复杂的炎症性疾病,其发生和发展与代谢重编程密切相关。脂代谢异常已被证实在IBD病理过程中发挥重要作用,不仅影响肠道屏障功能,还通过调控免疫细胞活化、炎症因子释放及氧化应激水平介导炎症反应。近年来,天然类黄酮因其广泛存在于食品中,并具有良好的抗炎、抗氧化及调节代谢功能,受到广泛关注。研究表明,天然类黄酮可通过调控脂质代谢因子、改善脂肪酸代谢途径及维持胆固醇稳态,从而影响肠道炎症的发展过程。然而,目前关于天然类黄酮通过脂代谢重编程影响IBD的具体作用机制仍有待深入探讨。本文综述了脂代谢重编程在IBD中的作用机制,探讨了天然类黄酮在脂代谢调控中的潜在价值,并分析其通过脂代谢重编程缓解IBD的可能机制,以期为IBD的膳食干预提供新的研究思路和科学依据。

Abstract:

With the development of economy and society, the shift from monotonous dietary habits to diverse eating patterns has increasingly burdened intestinal systems, leading to a yearly rise in patients with chronic inflammatory bowel disease (IBD). As a complex inflammatory disorder, the occurrence and progression of IBD are closely associated with metabolic reprogramming. Dysregulated lipid metabolism has been proven to play significant roles in IBD pathogenesis, not only affecting intestinal barrier function but also mediating inflammatory responses through regulating immune cell activation, inflammatory cytokine release, and oxidative stress levels. In recent years, natural flavonoids have attracted extensive attention due to their widespread presence in foods and their excellent anti-inflammatory, antioxidant, and metabolic regulatory properties. Studies indicate that natural flavonoids can influence the progression of intestinal inflammation by regulating lipid metabolism factors, improving fatty acid metabolic pathways, and maintaining cholesterol homeostasis. However, the specific mechanisms by which natural flavonoids affect IBD through lipid metabolism reprogramming remain to be thoroughly investigated. This review summarizes the mechanistic roles of lipid metabolism reprogramming in IBD, explores the potential value of natural flavonoids in lipid metabolism regulation, and analyzes their possible mechanisms in alleviating IBD through metabolic reprogramming, aiming to provide new research perspectives and scientific evidence for dietary interventions in IBD management.